HTS - High Throughput Screening

High Throughput Screening (HTS) is now optimized using a 96 SCP Head.  With the ability of independently controlling each tip with individual volumes and volume verification, an entire 96 well compound sample plate may be diluted and mixed in a single step.  By using a worklist protocol method, it is now possible to take a compound plate that has an electronic file containing each wells compound, volume and concentration are used to calculate a corresponding amount of DMSO to dilute all the compounds to a standard concentration.

The 96 SCP Head can be used to dilute compound plates for a HTS assay in multiple high throughput ways:

1. An entire 96 well compound plate can be diluted with different volumes in one aspirate and dispense step.
2. A 384 well compound plate may be diluted in 5 steps with a single aspiration and 4 dispenses since the head may multi-pipet different volumes over multiple plates.
3. A serial diluted plate may be created by picking up either single rows of columns of tips to run the serial dilution over a single plate.

In addition, the single channel independent tips may also perform any of the above tasks with the same performance and validation and is required for applications like hit picking for a secondary screen when individual well and / or tube access is required.