Real time quality control in liquid transfer operations can eliminate false assay results due to transfer failures using the Seyonic closed-loop Sensor Controlled Pipetting (SCP) device. Real-time data acquisition enables the detection of ordinary fault conditions like clogged tips or unexpected empty source wells and can activate automatic recovery actions without human intervention. Exported quality data of EVERY liquid transfer operation with an automated system can be used for bio-informatics data analysis as well as documentation for regulatory agencies.